Informace o projektu
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Kód projektu
- LM2018127
- Období řešení
- 1/2020 - 12/2022
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
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Středoevropský technologický institut
- prof. RNDr. Vladimír Sklenář, DrSc.
- Spolupracující organizace
-
Biotechnologický ústav AV ČR, v.v.i.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Cíle udržitelného rozvoje
Masarykova univerzita se hlásí k cílům udržitelného rozvoje OSN, jejichž záměrem je do roku 2030 zlepšit podmínky a kvalitu života na naší planetě.
Publikace
Počet publikací: 185
2025
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Synthesis of bambusurils with perfluoroalkylthiobenzyl groups as highly potent halide receptors
Organic Chemistry Frontiers, rok: 2025, ročník: 12, vydání: 1, DOI
2024
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Carboxy-terminal polyglutamylation regulates signaling and phase separation of the Dishevelled protein
EMBO Journal, rok: 2024, ročník: 43, vydání: 22, DOI
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Computational Design of Pore-Forming Peptides with Potent Antimicrobial and Anticancer Activities
Journal of Medicinal Chemistry, rok: 2024, ročník: 67, vydání: 16, DOI
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Endosome rupture enables enteroviruses from the family <i>Picornaviridae</i> to infect cells
Communications Biology, rok: 2024, ročník: 7, vydání: 1, DOI
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Glutamine and serum starvation alters the ATP production, oxidative stress, and abundance of mitochondrial RNAs in extracellular vesicles produced by cancer cells
Scientific Reports, rok: 2024, ročník: 14, vydání: 1, DOI
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Growth Phase Matters: Boosting immunity via Lacticasebacillus-derived membrane vesicles and their interactions with TLR2 pathways
Journal of Extracellular Biology, rok: 2024, vydání: 3, DOI
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Merging Bambus[6]uril and Biotin[6]uril into an Enantiomerically Pure Monofunctionalized Hybrid Macrocycle
Organic Letters, rok: 2024, ročník: 26, vydání: 1, DOI
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Myc 9aaTAD activation domain binds to mediator of transcription with superior high affinity
Molecular Medicine, rok: 2024, ročník: 30, vydání: 1, DOI
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Proteogenomic Classification of Triple-Negative Breast Cancer for Prognosis and Targeted therapy
Rok: 2024, druh: Konferenční abstrakty
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Structure and replication cycle of a virus infecting climate-modulating alga Emiliania huxleyi
Science advances, rok: 2024, ročník: 10, vydání: 15, DOI