Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen

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Publikace nespadá pod Pedagogickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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RADOLF Justin D. DEKA Ranjit K. ANAND Arvind ŠMAJS David NORGARD Michael V. YANG X. Frank

Rok publikování 2016
Druh Článek v odborném periodiku
Časopis / Zdroj Nature Reviews Microbiology
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.1038/nrmicro.2016.141
Obor Mikrobiologie, virologie
Klíčová slova OUTER-MEMBRANE PROTEIN; PYROPHOSPHATE-DEPENDENT PHOSPHOFRUCTOKINASE; LYME-DISEASE SPIROCHETE; WHOLE GENOME SEQUENCE; BORRELIA-BURGDORFERI; SECONDARY SYPHILIS; PHOSPHOTRANSFERASE SYSTEM; BINDING PROTEIN; SUBSP PALLIDUM; ANTIGENIC VARIATION
Popis The past two decades have seen a worldwide resurgence in infections caused by Treponema pallidum subsp. pallidum, the syphilis spirochete. The well-recognized capacity of the syphilis spirochete for early dissemination and immune evasion has earned it the designation ‘the stealth pathogen’. Despite the many hurdles to studying syphilis pathogenesis, most notably the inability to culture and to genetically manipulate T. pallidum, in recent years, considerable progress has been made in elucidating the structural, physiological, and regulatory facets of T. pallidum pathogenicity. In this Review, we integrate this eclectic body of information to garner fresh insights into the highly successful parasitic lifestyles of the syphilis spirochete and related pathogenic treponemes.
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