3D electromechanical cell biosensors for drug and disease screening
| Autoři | |
|---|---|
| Rok publikování | 2025 |
| Druh | Vyžádané přednášky |
| Citace | |
| Popis | Human cardiomyocytes derived from pluripotent stem cell lines in 3D organoids provide a non- invasive and long-term “organ-on-a-chip” platform for functional analysis. By integrating microelectrode array electrophysiology, atomic force microscopy–based contractility, and calcium imaging, this approach links electrical activity with mechanical force in real time. The system enables testing of novel and established drugs, including combinations, and has revealed, for instance, the pro- arrhythmic potential of pulmonary bronchodilators. Applications extend to both wild-type cells and disease-specific lines, such as Duchenne muscular dystrophy or catecholaminergic polymorphic ventricular tachycardia. We present this methodology together with its clinical relevance and introduce a new model for translational research. |
| Související projekty: |