Sex-Specific Temporal Proteomic Signatures in the Juvenile Rat Hippocampus After Pilocarpine-Induced Status Epilepticus

• Autoři: SHAKERZADEH Jalleh; JAROUŠEK Radim; GOLIÁŠOVÁ Zita; BRÁZDIL Milan; KUBOVA H.
• Rok publikování: 2025
• Druh: Další prezentace na konferencích
• Fakulta / Pracoviště MU: Lékařská fakulta

Přiložené soubory

• ILAE.Abstract.pdf

• Popis: • Early-life seizures are a major risk factor for long-term neurodevelopmental problems and chronic epilepsy. • The immature brain responds differently to injury compared to the adult brain, with sex influencing both vulnerability and recovery patterns. • Status epilepticus during development can trigger widespread molecular changes in the hippocampus that shape the course of epileptogenesis. • Studying these changes over time provides insight into the balance between injury and repair, and may reveal why outcomes differ between males and females.

Související projekty

• Národní ústav pro neurologický výzkum