Human Treponema pallidum 11q/j isolate belongs to subsp. endemicum but contains two loci with a sequence in TP0548 and TP0488 similar to subsp. pertenue and subsp. pallidum, respectively

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Publikace nespadá pod Pedagogickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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MIKALOVÁ Lenka STROUHAL Michal OPPELT Jan GRANGE Philippe Alain JANIER Michel BENHADDOU Nadjet DUPIN Nicolas ŠMAJS David

Rok publikování 2017
Druh Článek v odborném periodiku
Časopis / Zdroj PLoS neglected tropical diseases
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005434
Doi http://dx.doi.org/10.1371/journal.pntd.0005434
Obor Epidemiologie, infekční nemoci a klinická imunologie
Klíčová slova Treponema pallidum
Popis The TEN 11q/j isolate was characterized using nested PCR followed by Sanger sequencing and/or direct Illumina sequencing. Altogether, 44 chromosomal regions were analyzed. Overall, the 11q/j isolate clustered with TEN strains Bosnia A and Iraq B as expected from previous TEN classification of the 11q/j isolate. However, the 11q/j sequence in a 505 bp-long region at the TP0488 locus was similar to Treponema pallidum subsp. pallidum (TPA) strains, but not to TEN Bosnia A and Iraq B sequences, suggesting a recombination event at this locus. Similarly, the 11q/j sequence in a 613 bp-long region at the TP0548 locus was similar to Treponema pallidum subsp. pertenue (TPE) strains, but not to TEN sequences.
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