Behavioural sensitization to methamphetamine affects expression of cannabinoid CB1 receptors in mouse midbrain.

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Authors	LANDA Leoš JURAJDA Michal
Year of publication	2007
Type	Article in Periodical
Magazine / Source	Behavioural Pharmacology
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	behavioural sensitization; methamphetamine; PCR
Description	The behavioural part of experiment showed stimulatory influence of methamphetamine (Met) after the acute administration and initiation of sensitization to Met after repeated treatment. Real-time PCR results showed increased CB1 mRNA expression after Met first dose followed by decrease in CB1 mRNA expression after the last dose of repeated treatment.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.