Impact of cannabinoid receptor ligands on behavioural sensitization to antiaggressive methamphetamine effects in the model of mouse agonistic behaviour

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Authors	LANDA Leoš ŠLAIS Karel ŠULCOVÁ Alexandra
Year of publication	2006
Type	Article in Periodical
Magazine / Source	Neuroendocrinology Letters
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	methamphetamine; cannabinoids; behavioural sensitization; aggressiveness; mice
Description	Repeated administration of methamphetamine elicited a significant sensitization to its antiaggressive effects. Methanandamide pre-treatment provoked cross-sensitization to this methamphetamine effect, whereas pre-treatment with JWH 015 did not. Combined pre-treatment with methamphetamine+AM 251 suppressed the sensitization to antiaggressive effects of methamphetamine.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.