Effect of ajmaline on action potential and ionic currents in rat ventricular myocytes

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Authors	BÉBAROVÁ Markéta MATEJOVIČ Peter PÁSEK Michal ŠIMURDOVÁ Milena ŠIMURDA Jiří
Year of publication	2005
Type	Article in Periodical
Magazine / Source	General Physiology and Biophysics
MU Faculty or unit	Faculty of Medicine
Citation
Field	Physiology
Keywords	ajmaline; action potential; ionic currents; concentration dependence; rat ventricular myocytes
Description	Ajmaline decreased the upstroke velocity of action potential and action potential amplitude, increased the action potential duration measured at 50 and 90% repolarization, and reversibly inhibited most components of membrane ionic current in a concentration-dependent manner; IC50 was 27.8 umol/l for INa, 70.8 umol/l for ICa, 25.9 umol/l for Ito, 61.0 umol/l for IK, and 13.3 umol/l for IKATP.
Related projects:	Early diagnostics and treatment of cardiovascular diseases