Effect of mirtazapine and paroxetine on residual symptoms of depressive disorders and their effect on P450 CYP 2D6 activity

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Authors	ŽOURKOVÁ Alexandra
Year of publication	2001
Type	Article in Periodical
Magazine / Source	Homeostasis
MU Faculty or unit	Faculty of Medicine
Citation
Field	Psychiatry, sexuology
Keywords	depressive disorder-residual symptoms-CYP 2D6-poor metaboliser-extensive metaboliser
Description	The issues related to preventing a relapse of depressive disorder are high on the list of priorities of psychiatry.The achievement of only a partial remission is a predictor of a higher incidence of relapses.30 patients displaying residual symptoms of depressive disorder were treated with paroxetine or mirtazapine in the conditions of a double-blind study involving monitoring CYP 2D6 activity.Both mirtazapine and paroxetine had a positive effect on residual symptoms of depressive disorder.
Related projects:	Phenotype dynamics in patient treated by paroxetine regarding the clinical correlates Plasticity of Regulatory Mechanisms of the Central Nervous Systems