Influence of ligands of serotonin receptors on the drug-metabolizing processes in the isolated perfused rat liver

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Authors	SLÍVA Jiří DOSTÁLEK Miroslav HADAŠOVÁ Eva TOMANDL Josef
Year of publication	2002
Type	Article in Periodical
Magazine / Source	Bratislavské lekárské listy
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	izolated perfused liver; CYP2D1
Description	The effects of selective ligands of 5-HT3 and 5-HT1A/1B receptors, tropisetrone and RU 249, on N-acetylation and cytochrome P460-mediated metabolism in the isolated perfused rat liver were followed. The study has shown significant inhibition of acetylation, but a marked stimulation of CYP 2D1 activity after administration of both substances, with higher significance in RU 24969.
Related projects:	Plasticity of Regulatory Mechanisms of the Central Nervous Systems