Zhodnocení dosavadních zkušeností s dynamikou aktivity CYP2D6

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Title in English	Evaluation of the current experience with the dynamics of CYP2D6 activity
Authors	ZELENKOVÁ Olga ČEŠKOVÁ Eva HADAŠOVÁ Eva ŽOURKOVÁ Alexandra
Year of publication	2002
Type	Article in Periodical
Magazine / Source	Psychiatrie
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	Genetic polymorphism; CYP2D6; psychiatry; enzyme inhibition;
Description	The study followed the dynamics of the metabolic capacity of CYP2D6 during the 28-day treatment with various psychotropic drugs. It was confirmed that the psychopharmacotherapy may change the CYP2D6 phenotype from the extensive (EM) to the poor (PM) metabolic phenotype.
Related projects:	Plasticity of Regulatory Mechanisms of the Central Nervous Systems